Trifluoromethylated lactams: promising small molecules in the search for effective drugs

Monika Bilska-Markowska, Tomasz Cytlak and Marcin Kaźmierczak

Chem. Commun., 2025, 61, 785
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Chiral phosphoric acid-catalyzed enantioselective synthesis of biphenyl-bridged ε-sultams via the Friedel–Crafts reactions of cyclic N-sulfonylimines with indolizines

Qian Li, Yuan-Yuan Xu, Bi-Xi Feng, Tao Wang and You-Qing Wang

Org. Chem. Front., 2024, 11, 4829
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An N-heterocyclic carbene-catalyzed enantioselective [3 + 2] annulation of enals with propargylic imines: access to γ,γ-disubstituted pyrrolidin-2-ones bearing quaternary stereogenic centers

Jianming Zhang, Zheng Liang, Simiao Zhang, Lei Chen, Xiaoxue Wang, Yuchan Wang, Jie Feng, Tao Lu, Ding Du and Jian Gao

Org. Chem. Front., 2022, 9, 3763
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Tale of the Breslow intermediate, a central player in N-heterocyclic carbene organocatalysis: then and now

Monika Pareek, Yernaidu Reddi and Raghavan B. Sunoj

Chem. Sci., 2021, 12, 7973
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Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity

Mei-Mei Li, Xiaozhen Chen, Yun Deng and Jun Lu

RSC Adv., 2021, 11, 38060
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Asymmetric synthesis of γ-lactams under low-loading N-heterocyclic carbene catalysis

Yuxia Zhang, Ye Zhang, Jingcheng Guo, Jinna Han, Xiangui Zhou and Zhenqian Fu

Org. Chem. Front., 2021, 8, 5087
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The N-heterocyclic carbene-catalyzed [3 + 2] annulation of isoindigos with enals: the enantioselective construction of three contiguous stereogenic centers

Binghao Liu, Jing Qi, Yatong Wu, Jia-Hui Li, Yanting Li and Xiao-Yong Duan

Org. Chem. Front., 2022, 9, 3552
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Pd-catalyzed [3 + 2] cycloaddition of cyclic ketimines and trimethylenemethanes toward N-fused pyrrolidines bearing a quaternary carbon

Seoung-Mi Choi, Kyeong Do Kim, Jong-Un Park, Zi Xuan and Ju Hyun Kim

RSC Adv., 2022, 12, 785
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Asymmetric Construction of γ-lactams Displaying All-carbon, Aza-, Thia- and Oxaquaternary Chiral Centers

Mario Orena and Samuele Rinaldi

COC, 2023, 27, 1292
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Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe

Michael Fragkiadakis, Eirini Fotopoulou, Konstantinos G. Froudas and Constantinos G. Neochoritis

Eur J Org Chem, 2024, 27
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Brønsted Base‐Catalyzed Formal Reductive [3+2] Annulation of 4,4,4‐Trifluorocrotonate and α‐Iminoketones

Azusa Kondoh and Masahiro Terada

Chemistry A European J, 2021, 27, 585
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Synthesis of Polycyclic Imidazolidinones via Cascade [3 + 2]-Annulation of β-Oxo-acrylamides with Cyclic N-Sulfonyl Imines

Lei Xie, Chenyi Zhao, Zhaoxue Wang, Zirui Chen, Yingying Zhao, Xinghan Liu, Xiangdong Xu, Wanxing Liu, Xiaojing Li and Lingang Wu

J. Org. Chem., 2023, 88, 15805
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C2-Symmetric 1,2-Diphenylethane-1,2-diamine-Derived Primary–Tertiary Diamine-Catalyzed Asymmetric Mannich Addition of Cyclic N-Sulfonyl Trifluoromethylated Ketimines

Hui-Xin Duan, Yongna Zhang, Zhen-Zhen Zhang and You-Qing Wang

J. Org. Chem., 2020, 85, 11331
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N-Heterocyclic Carbene Catalyzed the Umpolung of Aldehyde Compounds

Ming Zhao, Rui Yan and Hu Chen

Chinese Journal of Organic Chemistry, 2024, 44, 2204
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Assembly of versatile fluorine-containing structures via N-heterocyclic carbene organocatalysis

Bei Zhang and Jian Wang

Sci. China Chem., 2022, 65, 1691
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Theoretical Insights into Enantioselective [3 + 2] Cycloaddition between Cinnamaldehyde and Cyclic N-Sulfonyl Trifluoromethylated Ketimine Catalyzed by N-Heterocyclic Carbene

Jingyi Shen, Yan Zhang and Ying Xue

J. Phys. Chem. A, 2022, 126, 3124
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NHC-catalyzed N H functionalization/cycloaddition reaction of indole aldehyde and ketone: A DFT perspective

Lujun Zhang and Yang Wang

Computational and Theoretical Chemistry, 2023, 1220, 114007
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Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates

Malla Reddy Gannarapu, Takanori Imai, Kentaro Iwaki, Seiji Tsuzuki and Norio Shibata

Commun Chem, 2021, 4
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Organocatalytic Enantioselective Synthesis of [5.7]-Fused ε-Sultam N,O-Heterocycles via (3 + 2)-Annulation of Seven-Membered Cyclic N-Sulfonylimines with γ-Hydroxy-α,β-Unsaturated Ketones

Ying Du, Peng Han, Tao Wang and You-Qing Wang

J. Org. Chem., 2024, 89, 18698
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N‐Heterocyclic Carbene Catalyzed [3+2] Annulations of β‐Halocycloenals with Isatins and Mechanism Study

Gang Wang, Jiang Wu, Hang Cheng, Cheng Zhong and Zhao‐Lin He

Eur J Org Chem, 2021, 2021, 983
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Unraveling the mechanism and substituent effects on the N-heterocyclic carbene-catalyzed transformation reaction of enals and imines

Shuang-Liang Liu, Xiaoqian Liu, Yang Wang and Donghui Wei

Molecular Catalysis, 2022, 519, 112122
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Ligand-Enabled Palladium-Catalyzed Asymmetric Synthesis of Cyclic Sulfamidate-Fused Imidazolidinones

Zhengyi Yi, Weixin Xiao, Jiyang Jie, Haijun Yang and Hua Fu

Org. Lett., 2025, 27, 6330
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Palladium‐catalyzed [4 + 2] cycloaddition of sulfamate‐derived cyclic imines with γ‐methylidene‐δ‐valerolactones/2‐methylidenetrimethylene carbonate

Ke‐Xin Huang, Wen‐Jie Wu, Zhao‐Yang Chen, Jia Du and Wen‐Chao Gao

Journal of Heterocyclic Chem, 2024, 61, 1035
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Improvement of Asymmetric Reactions via Remote Electronic Tuning of N‐Heterocyclic Carbene Catalysts

Tsubasa Inokuma and Ken‐ichi Yamada

ChemCatChem, 2024, 16
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