Microfluidics-aided fabrication of 3D micro-nano hierarchical SERS substrate for rapid detection of dual hepatocellular carcinoma biomarkers

Changbiao Zhan, Zihao Guan, Liandong Yu, Tongmei Jing, Huakun Jia, Xiaozhe Chen and Rongke Gao

Lab Chip, 2024, 24, 528
DOI: 10.1039/D3LC00907F

Investigation of hairpin DNA and chelerythrine interaction by a single bio-nanopore sensing interface

Yuan-Min Liu, Xiu-Yu Fang, Fang Fang and Zhi-Yong Wu

Analyst, 2019, 144, 4081
DOI: 10.1039/C9AN00113A

Nanopore-based measurement of the interaction of P450cam monooxygenase and putidaredoxin at the single-molecule level

Hui Chen, Yao Lin, Yi-Tao Long, Shelley D. Minteer and Yi-Lun Ying

Faraday Discuss., 2022, 233, 295
DOI: 10.1039/D1FD00042J

Application of Nanopore Sensors for Biomolecular Interactions and Drug Discovery

Ki‐Baek Jeong, Jin‐Sik Kim, Naresh Niranjan Dhanasekar, Mi‐Kyung Lee and Seung‐Wook Chi

Chemistry An Asian Journal, 2022, 17
DOI: 10.1002/asia.202200679

Single-molecule RNA sizing enables quantitative analysis of alternative transcription termination

Gerardo Patiño-Guillén, Jovan Pešović, Marko Panić, Dušanka Savić-Pavićević, Filip Bošković and Ulrich Felix Keyser

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-45968-8

The fluorescence amplification strategy based on 3D DNA walker and CRISPR/Cas12a for the rapid detection of BRAF V600E

Wenxiu Zhang, Shuhui Zhao, Zuowei Xie, Siyi Chen, Yuqi Huang, Zixin Zhao and Gang Yi

ANAL. SCI., 2022, 38, 1057
DOI: 10.1007/s44211-022-00131-5

Evaluation of Nanopore Sensor Design Using Electrical and Optical Analyses

Lauren A. Mayse, Ali Imran, Yazheng Wang, Mohammad Ahmad, Rebecca A. Oot, Stephan Wilkens and Liviu Movileanu

ACS Nano, 2023, 17, 10857
DOI: 10.1021/acsnano.3c02532

Recent advances in single-entity electrochemistry for metal nanoparticle, nanodroplet, and bio-entity analysis

Jee Woo Kim, Gowrisankar Aruchamy and Byung-Kwon Kim

TrAC Trends in Analytical Chemistry, 2023, 169, 117358
DOI: 10.1016/j.trac.2023.117358

Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells

Ru‐Jia Yu, Yi‐Lun Ying, Rui Gao and Yi‐Tao Long

Angew Chem Int Ed, 2019, 58, 3706
DOI: 10.1002/anie.201803229

Real-time measurement of protein–protein interactions at single-molecule resolution using a biological nanopore

Avinash Kumar Thakur and Liviu Movileanu

Nat Biotechnol, 2019, 37, 96
DOI: 10.1038/nbt.4316

Intelligent Quantification of Picomolar Protein Concentration in Serum by Functionalized Nanopores

Naren Das, R. Ray, S. Ray and Chirasree Roychaudhuri

IEEE Sensors J., 2018, 18, 10183
DOI: 10.1109/JSEN.2018.2872853

Electrochemical microRNA detection based on catalytic deposition of G-quadruplex DNAzyme in nanochannels

Fei Zhao, Wenwen Xue and Hongfang Zhang

J Appl Electrochem, 2022, 52, 885
DOI: 10.1007/s10800-022-01673-2

Combining ionic diode, resistive pulse and membrane for detection and separation of anti-CD44 antibody

Imad Abrao-Nemeir, Oumaima Zaki, Nathan Meyer, Mathilde Lepoitevin, Joan Torrent, Jean-Marc Janot and Sebastien Balme

Journal of Membrane Science, 2022, 649, 120391
DOI: 10.1016/j.memsci.2022.120391

Solid-State Nanopore Single-Molecule Sensing of DNAzyme Cleavage Reaction Assisted with Nucleic Acid Nanostructure

Libo Zhu, Ying Xu, Irshad Ali, Liping Liu, Hongwen Wu, Zuhong Lu and Quanjun Liu

ACS Appl. Mater. Interfaces, 2018, 10, 26555
DOI: 10.1021/acsami.8b09505

Single-Molecule Observation of Competitive Protein–Protein Interactions Utilizing a Nanopore

Jiaxin Sun, Antun Skanata and Liviu Movileanu

ACS Nano, 2025, 19, 1103
DOI: 10.1021/acsnano.4c13072

Pore-forming confined space for the innovative electrochemical methods

Kaipei Qiu, Xue-Yuan Wu, Jie Yang, Yi-Lun Ying and Yi-Tao Long

Current Opinion in Electrochemistry, 2018, 10, 46
DOI: 10.1016/j.coelec.2018.03.037

Single-Molecule Investigation of the Protein–Aptamer Interactions and Sensing Application Inside the Single Glass Nanopore

Mengya Cao, Lijun Zhang, Haoran Tang, Xia Qiu and Yongxin Li

Anal. Chem., 2022, 94, 17405
DOI: 10.1021/acs.analchem.2c02660

Ribosome Fingerprinting with a Solid-State Nanopore

Mukhil Raveendran, Anna Rose Leach, Tayah Hopes, Julie L. Aspden and Paolo Actis

ACS Sens., 2020, 5, 3533
DOI: 10.1021/acssensors.0c01642

Open Circuit Potential as a Tool for the Assessment of Binding Kinetics and Reagentless Protein Quantitation

Mohamed Sharafeldin, Timothy James and Jason J. Davis

Anal. Chem., 2021, 93, 14748
DOI: 10.1021/acs.analchem.1c03292

Recent Advances in Solid Nanopore/Channel Analysis

Zi Long, Shenshan Zhan, Pengcheng Gao, Yongqian Wang, Xiaoding Lou and Fan Xia

Anal. Chem., 2018, 90, 577
DOI: 10.1021/acs.analchem.7b04737

Nanopore single-molecule analysis of biomarkers: Providing possible clues to disease diagnosis

Xiaohan Chen, Shuo Zhou, Yunjiao Wang, Ling Zheng, Sarah Guan, Deqiang Wang, Liang Wang and Xiyun Guan

TrAC Trends in Analytical Chemistry, 2023, 162, 117060
DOI: 10.1016/j.trac.2023.117060

Detektieren mit Nanopipetten im eingeschränkten Raum: von einzelnen Molekülen über Nanopartikel hin zu der Zelle

Ru‐Jia Yu, Yi‐Lun Ying, Rui Gao and Yi‐Tao Long

Angewandte Chemie, 2019, 131, 3744
DOI: 10.1002/ange.201803229

Nanopore confinement for electrochemical sensing at the single-molecule level

Yao Lin, Yi-Lun Ying and Yi-Tao Long

Current Opinion in Electrochemistry, 2018, 7, 172
DOI: 10.1016/j.coelec.2017.12.002

Non-linear mass transport in confined nanofluidic devices for label-free bioanalysis/sensors

Fei-Fei Liu, Xiao-Ping Zhao, Bin Kang, Xing-Hua Xia and Chen Wang

TrAC Trends in Analytical Chemistry, 2020, 123, 115760
DOI: 10.1016/j.trac.2019.115760

Non-Receptor-Mediated Lipid Membrane Permeabilization by the SARS-CoV-2 Spike Protein S1 Subunit

Alina Asandei, Loredana Mereuta, Irina Schiopu, Jonggwan Park, Chang Ho Seo, Yoonkyung Park and Tudor Luchian

ACS Appl. Mater. Interfaces, 2020, 12, 55649
DOI: 10.1021/acsami.0c17044

Functionalized nanopores based on hybridization chain reaction: Fabrication and microRNA sensing

Xia Qiu, Jingyi Dong, Qingshan Dai, Mimi Huang and Yongxin Li

Biosensors and Bioelectronics, 2023, 240, 115594
DOI: 10.1016/j.bios.2023.115594

Protein Profiling by Nanopore-Based Technology

Funa Meng, Xin Li, Na Zou and Xueliang Wang

Anal. Chem., 2025, 97, 10110
DOI: 10.1021/acs.analchem.5c00992

Facile Fabrication of Gold Functionalized Nanopipette for Nanoscale Electrochemistry and Surface Enhanced Raman Spectroscopy

Hong-Na LI, Dan YANG, Ao-Xue LIU, Guo-Hui LIU, Yu-Ping SHAN, Guo-Cheng YANG and Jin HE

Chinese Journal of Analytical Chemistry, 2019, 47, e19104
DOI: 10.1016/S1872-2040(19)61177-1

Perspective on signal amplification strategies and sensing protocols in photoelectrochemical immunoassay

Chun-Qin Zhao and Shou-Nian Ding

Coordination Chemistry Reviews, 2019, 391, 1
DOI: 10.1016/j.ccr.2019.03.018

Manipulating and visualizing the dynamic aggregation-induced emission within a confined quartz nanopore

Yi-Lun Ying, Yuan-Jie Li, Ju Mei, Rui Gao, Yong-Xu Hu, Yi-Tao Long and He Tian

Nat Commun, 2018, 9
DOI: 10.1038/s41467-018-05832-y

Current pulse signature of native kanamycin aptamer and its implication for molecular interactions on a single protein nanopore sensing interface

Hui-Qing Shi, Yao Ma, Yu-Hang Wang, Fang Fang and Zhi-Yong Wu

Biosensors and Bioelectronics, 2022, 201, 113966
DOI: 10.1016/j.bios.2022.113966

Dynamic Chemistry Interactions: Controlled Single-Entity Electrochemistry

Si-Min Lu, Meng-Yin Li and Yi-Tao Long

J. Phys. Chem. Lett., 2022, 13, 4653
DOI: 10.1021/acs.jpclett.2c00960

Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel

Huabin Cai, Runhao Yuan, Shaokun Huang, Yanling Huang, Cuiying Lin, Yue Lin, Fang Luo, Zhenyu Lin and Lixin Wang

Talanta, 2025, 285, 127422
DOI: 10.1016/j.talanta.2024.127422

Biomimetic Nanochannel-Ionchannel Hybrid for Ultrasensitive and Label-Free Detection of MicroRNA in Cells

Xiao-Ping Zhao, Fei-Fei Liu, Wen-Chao Hu, Muhammad Rizwan Younis, Chen Wang and Xing-Hua Xia

Anal. Chem., 2019, 91, 3582
DOI: 10.1021/acs.analchem.8b05536

Solid-state and polymer nanopores for protein sensing: A review

Nathan Meyer, Imad Abrao-Nemeir, Jean-Marc Janot, Joan Torrent, Mathilde Lepoitevin and Sebastien Balme

Advances in Colloid and Interface Science, 2021, 298, 102561
DOI: 10.1016/j.cis.2021.102561

Single-Molecule Protein Detection in a Biofluid Using a Quantitative Nanopore Sensor

Avinash Kumar Thakur and Liviu Movileanu

ACS Sens., 2019, 4, 2320
DOI: 10.1021/acssensors.9b00848

Advanced Nanoscale Approaches to Single-(Bio)entity Sensing and Imaging

Marta Maria Pereira da Silva Neves and Daniel Martín-Yerga

Biosensors, 2018, 8, 100
DOI: 10.3390/bios8040100

A generalizable nanopore sensor for highly specific protein detection at single-molecule precision

Mohammad Ahmad, Jeung-Hoi Ha, Lauren A. Mayse, Maria F. Presti, Aaron J. Wolfe, Kelsey J. Moody, Stewart N. Loh and Liviu Movileanu

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-36944-9

Molecular diagnostics for infectious disease and cancer based on glass capillary nanopore sensing

Ryogo Higashi, Izumi Shibayama, Jiajue Ji, Tao Ren, Iiro Kiiski, Nanami Takeuchi and Ryuji Kawano

Current Opinion in Biotechnology, 2026, 97, 103394
DOI: 10.1016/j.copbio.2025.103394

Label-free analysis of adsorbed protein heterogeneity on individual particles, based on single particle collision events

Wei Yi, Cong Xu, Tianyi Xiong, Tienan Gao, Ping Yu, Xiaohua He and Lanqun Mao

Electrochemistry Communications, 2020, 111, 106666
DOI: 10.1016/j.elecom.2020.106666

Following the central dogma: Nanopore sequencing from DNA and RNA to proteins

Yutong Wang, Qian Han, Yilong He, Shumin Deng, Ziwei Huang, Ziyan Zhang, Shuaijian Dai and Zhuxin Dong

iScience, 2026, 29, 114835
DOI: 10.1016/j.isci.2026.114835

Stochastic Sensing of Dynamic Interactions and Chemical Reactions with Nanopores/Nanochannels

Xiaojin Zhang, Meihua Lin, Yu Dai and Fan Xia

Anal. Chem., 2023, 95, 10465
DOI: 10.1021/acs.analchem.3c00543

Nanopore-Based Single-Entity Electrochemistry for the Label-Free Monitoring of Single-Molecule Glycoprotein–Boronate Affinity Interaction and Its Sensing Application

Haoran Tang, Hao Wang, Dandan Zhao, Mengya Cao, Yanyan Zhu and Yongxin Li

Anal. Chem., 2022, 94, 5715
DOI: 10.1021/acs.analchem.2c00860

The Advance of Plasmonic-Electric Nanopipette Sensing in Single Cells

Yue Cao, You-Jia Yu, Qiao-Yan Jiang, Yang Sun, Zhengsheng Mao, Jie Wang and Feng Chen

Curr Pharmacol Rep, 2021, 7, 55
DOI: 10.1007/s40495-021-00249-6

Disentangling the recognition complexity of a protein hub using a nanopore

Lauren Ashley Mayse, Ali Imran, Motahareh Ghahari Larimi, Michael S. Cosgrove, Aaron James Wolfe and Liviu Movileanu

Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-28465-8

Current progress in glass-based nanochannels

Yixin Ling, Xuelian Yang, Lei Zhou, Zhenkang Lei, Yaqi Hou and Xu Hou

International Journal of Smart and Nano Materials, 2024, 15, 222
DOI: 10.1080/19475411.2024.2305544

Review of the use of nanodevices to detect single molecules

Takahito Ohshiro and Masateru Taniguchi

Analytical Biochemistry, 2022, 654, 114645
DOI: 10.1016/j.ab.2022.114645

Detection of Glutamate Decarboxylase Antibodies and Simultaneous Multi-Molecular Translocation Exploration by Glass Nanopores

Chongxin Tao, Yun Bai, Jiang Chen, Jing Lu, Yan Bi and Jian Li

Biosensors, 2024, 14, 255
DOI: 10.3390/bios14050255

Probing the Hepatitis B Virus E-Antigen with a Nanopore Sensor Based on Collisional Events Analysis

Ioana C. Bucataru, Isabela Dragomir, Alina Asandei, Ana-Maria Pantazica, Alina Ghionescu, Norica Branza-Nichita, Yoonkyung Park and Tudor Luchian

Biosensors, 2022, 12, 596
DOI: 10.3390/bios12080596

Confined Nanopipette-A new microfluidic approach for single cell analysis

Si-Min Lu and Yi-Tao Long

TrAC Trends in Analytical Chemistry, 2019, 117, 39
DOI: 10.1016/j.trac.2019.05.050

Recognition of Bimolecular Logic Operation Pattern Based on a Solid-State Nanopore

Han Yan, Zhen Zhang, Ting Weng, Libo Zhu, Pang Zhang, Deqiang Wang and Quanjun Liu

Sensors, 2020, 21, 33
DOI: 10.3390/s21010033

Electrochemiluminescence Aptasensor for Charged Targets through the Direct Regulation of Charge Density in Microchannels

Yanling Huang, Fang Luo, Jian Wang, Liang Wang, Bin Qiu, Cuiying Lin and Zhenyu Lin

Anal. Chem., 2021, 93, 17127
DOI: 10.1021/acs.analchem.1c04815

Real-Time Measurement of a Weak Interaction of a Transcription Factor Motif with a Protein Hub at Single-Molecule Precision

Lauren A. Mayse, Yazheng Wang, Mohammad Ahmad and Liviu Movileanu

ACS Nano, 2024, 18, 20468
DOI: 10.1021/acsnano.4c04857

Rapid and label-free identification of single foodborne pathogens using microfluidic pore sensors

Tao Yang, Zisheng Luo, Ricardo A. Wu, Li Li, Yanqun Xu, Tian Ding and Xingyu Lin

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.959317

Glass Capillary-Based Nanopores for Single Molecule/Single Cell Detection

Xin Guan, Haijuan Li, Limei Chen, Guohua Qi and Yongdong Jin

ACS Sens., 2023, 8, 427
DOI: 10.1021/acssensors.2c02102