Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Alexander L. Nielsen, Nima Rajabi, Norio Kudo, Kathrine Lundø, Carlos Moreno-Yruela, Michael Bæk, Martin Fontenas, Alessia Lucidi, Andreas S. Madsen, Minoru Yoshida and Christian A. Olsen

RSC Chem. Biol., 2021, 2, 612
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Development of a single-step fluorogenic sirtuin assay and its applications for high-throughput screening

Pan Wang, Di Chen, Jian-xiong An, Shu-xian Lin, Ting Liu, Yan Li, Lei Chen and Bin He

Org. Biomol. Chem., 2022, 20, 1243
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Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration

A. Vogelmann, M. Schiedel, N. Wössner, A. Merz, D. Herp, S. Hammelmann, A. Colcerasa, G. Komaniecki, JY. Hong, M. Sum, E. Metzger, E. Neuwirt, L. Zhang, O. Einsle, O. Groß, R. Schüle, H. Lin, W. Sippl and M. Jung

RSC Chem. Biol., 2022, 3, 468
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Fluorescent molecular probe-based activity and inhibition monitoring of histone deacetylases

Roopa, Bhanu Priya, Vandana Bhalla, Manoj Kumar and Naresh Kumar

Chem. Commun., 2021, 57, 11153
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The CD38 glycohydrolase and the NAD sink: implications for pathological conditions

Julianna D. Zeidler, Kelly A. Hogan, Guillermo Agorrody, Thais R. Peclat, Sonu Kashyap, Karina S. Kanamori, Lilian Sales Gomez, Delaram Z. Mazdeh, Gina M. Warner, Katie L. Thompson, Claudia C. S. Chini and Eduardo Nunes Chini

American Journal of Physiology-Cell Physiology, 2022, 322, C521
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New chemical tools for probing activity and inhibition of the NAD + -dependent lysine deacylase sirtuin 2

Sören Swyter, Matthias Schiedel, Daria Monaldi, Sándor Szunyogh, Attila Lehotzky, Tobias Rumpf, Judit Ovádi, Wolfgang Sippl and Manfred Jung

Phil. Trans. R. Soc. B, 2018, 373, 20170083
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The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications

Shumin Ouyang, Qiyi Zhang, Linlin Lou, Kai Zhu, Zeyu Li, Peiqing Liu and Xiaolei Zhang

Front. Pharmacol., 2022, 13
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Cyclic Peptide-Based Sirtuin Substrates

Di Chen, Lingling Yan and Weiping Zheng

Molecules, 2019, 24, 424
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Revealing chromatin-specific functions of histone deacylases

Carlos Moreno-Yruela and Beat Fierz

Biochemical Society Transactions, 2024, 52, 353
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Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

Andreas S. Madsen, Christian Andersen, Mohammad Daoud, Kristin A. Anderson, Jonas S. Laursen, Saswati Chakladar, Frank K. Huynh, Ana R. Colaço, Donald S. Backos, Peter Fristrup, Matthew D. Hirschey and Christian A. Olsen

Journal of Biological Chemistry, 2016, 291, 7128
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Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates

Tasha B. Toro, Jenae R. Bryant and Terry J. Watt

Biochemistry, 2017, 56, 4549
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A one-step specific assay for continuous detection of sirtuin 2 activity

Qi Dai, Zhihua Zheng, Fan Xia, Peiqing Liu and Min Li

Acta Pharmaceutica Sinica B, 2019, 9, 1183
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A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography

Robin E. Bonomi, Maxwell Laws, Vadim Popov, Swatabdi Kamal, Shreya Potukutchi, Aleksandr Shavrin, Xin Lu, Nashaat Turkman, Ren-Shyan Liu, Thomas Mangner and Juri G. Gelovani

Mol Imaging Biol, 2018, 20, 594
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Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action

Vitor F. Martins, Maedha Begur, Shivani Lakkaraju, Kristoffer Svensson, Ji Park, Byron Hetrick, Carrie. E. McCurdy and Simon Schenk

American Journal of Physiology-Cell Physiology, 2019, 317, C964
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Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1–3 Inhibitors

Jun Young Hong, Irma Fernandez, Ananya Anmangandla, Xuan Lu, Jessica Jingyi Bai and Hening Lin

ACS Chem. Biol., 2021, 16, 1266
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SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs

K. P. Divya, Navjot Kanwar, P. V. Anuranjana, Gautam Kumar, Fathima Beegum, Krupa Thankam George, Nitesh Kumar, K. Nandakumar and Abhinav Kanwal

Cardiovasc Toxicol, 2024, 24, 598
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Bivalent SIRT1 inhibitors

Juan Wang, Wenwen Zang, Jiajia Liu and Weiping Zheng

Bioorganic & Medicinal Chemistry Letters, 2017, 27, 180
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Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**

Julie E. Bolding, Alexander L. Nielsen, Iben Jensen, Tobias N. Hansen, Line A. Ryberg, Samuel T. Jameson, Pernille Harris, Günther H. J. Peters, John M. Denu, Joseph M. Rogers and Christian A. Olsen

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High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays

Carlos Moreno-Yruela and Christian A. Olsen

STAR Protocols, 2021, 2, 100313
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Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020

Eslam Roshdy, Muhamad Mustafa, Abd El-Rahman Shaltout, Mohamed O. Radwan, Mahmoud A.A. Ibrahim, Mahmoud E. Soliman, Mikako Fujita, Masami Otsuka and Taha F.S. Ali

European Journal of Medicinal Chemistry, 2021, 224, 113709
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Peptide‐Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real‐Time Detection of Lysine Deacylation

Debra R. Rooker, Yuliya Klyubka, Ritika Gautam, Elisa Tomat and Daniela Buccella

ChemBioChem, 2018, 19, 496
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Sirtuin 6: A potential therapeutic target for cardiovascular diseases

Xie Saiyang, Wei Deng and Tang Qizhu

Pharmacological Research, 2021, 163, 105214
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Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**

Julie E. Bolding, Alexander L. Nielsen, Iben Jensen, Tobias N. Hansen, Line A. Ryberg, Samuel T. Jameson, Pernille Harris, Günther H. J. Peters, John M. Denu, Joseph M. Rogers and Christian A. Olsen

Angew Chem Int Ed, 2023, 62
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