Issue 34, 2022

Oxygen-powered flower-like FeMo6@CeO2 self-cascade nanozymes: a turn-on enhancement fluorescence sensor

Abstract

Enzyme cascade reactions in organisms have sparked tremendous interest for their coupled catalysis-facilitated efficient biochemical reactions. However, multi-enzyme cascade nanozymes remain largely unused. In the work, flower-like porous ceria-based integrated enzymes (INAzyme), FeMo6@CeO2 (FMC-n), were readily prepared using an efficient thermally induced process. Owing to a larger specific surface area and excellent adsorption, the flower-like matrix (CeO2) can serve as not only an effective sorbent for the conversion of dissolved oxygen in solution but also an excellent support for self-cascade reactions with FeMo6. Based on the electron transfer through Fe and Ce cycles, FMC-n INAzyme exhibits intrinsic oxidase-, peroxidase- and Fenton-like activities. Moreover, by assessing the Vo mobility and F-Vo relative content of FMC-2 and FC-66, we found that the contribution of enhanced accessibility through the specific surface area (SSA) to the activity of the INAzyme is significantly higher than the active sites. Finally, a fluorescence turn-on enhancement sensing platform based on self-cascade FMC-n for the detection of Cys was established, culminating in a LOD of as low as 0.014 μM in the range of 1–100 μM.

Graphical abstract: Oxygen-powered flower-like FeMo6@CeO2 self-cascade nanozymes: a turn-on enhancement fluorescence sensor

Supplementary files

Article information

Article type
Paper
Submitted
11 jul 2022
Accepted
29 jul 2022
First published
01 aug 2022

J. Mater. Chem. B, 2022,10, 6425-6432

Oxygen-powered flower-like FeMo6@CeO2 self-cascade nanozymes: a turn-on enhancement fluorescence sensor

Z. Tong, T. Wang, Y. Cai, J. Sha and T. Peng, J. Mater. Chem. B, 2022, 10, 6425 DOI: 10.1039/D2TB01466A

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