Issue 20, 2022

Serum fingerprinting by slippery liquid-infused porous SERS for non-invasive lung cancer detection

Abstract

Lung cancer (LC) remains the most commonly diagnosed cancer. Timely diagnosis is crucial for improving the clinical outcomes of LC patients. Serum molecular patterns reflect the physiological and pathological status of individuals, and are promising as diagnostic targets for malignancies. Here, we report a spectroscopic method for the rapid identification of LC based on the label-free fingerprinting of clinical serum samples with slippery liquid-infused porous surface-enhanced Raman spectroscopy (SLIPSERS). We first demonstrate the capability of SLIPSERS for the delivery and preconcentration of serum molecules into the SERS hot spots from an evaporating liquid droplet, enabling the acquisition of vibrational fingerprints of serum molecules with only 1 μL of blood serum in minutes. The averaged SLIPSERS signals of the serum sample from a cohort of 33 LC patients and 23 healthy controls reveal both metabolic and biomacromolcular alterations under LC conditions. By analyzing the SLIPSERS data with chemometric methods, we further demonstrate that the SLIPSERS profiling of serum molecular patterns allows the reliable discrimination of LCs from healthy controls. Considering the ease of operation and high efficiency, our SLIPSERS-based serum biopsy method should hold great potential for non-invasive LC diagnosis.

Graphical abstract: Serum fingerprinting by slippery liquid-infused porous SERS for non-invasive lung cancer detection

Supplementary files

Article information

Article type
Paper
Submitted
12 aug 2022
Accepted
08 sep 2022
First published
08 sep 2022

Analyst, 2022,147, 4426-4432

Serum fingerprinting by slippery liquid-infused porous SERS for non-invasive lung cancer detection

C. Cai, Y. Liu, J. Li, L. Wang and K. Zhang, Analyst, 2022, 147, 4426 DOI: 10.1039/D2AN01325H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements