Issue 15, 2021

Tumor microenvironment-activatable boolean logic supramolecular nanotheranostics based on a pillar[6]arene for tumor hypoxia imaging and multimodal synergistic therapy

Abstract

Supramolecular construction of nanotheranostics is a highly challenging and demanding task for tumor precision diagnosis and therapy. In this study, inspired by specific microenvironments and the abnormal metabolic path of tumors, we skillfully integrated hypoxia-responsive fluorescence imaging, cancer starvation therapy, oxidative therapy, and chemotherapy to fabricate supramolecular nanotheranostics (GOx@NPs) through host–guest interactions between a carboxylated-pillar[6]arene (WP6) host and a prodrug guest (Azo-G). Depending on the excellent responsive ability to hypoxia, esterase and pH which are signature features of the tumor microenvironment, GOx@NPs could not only realize selective fluorescence imaging and diagnosis against tumor hypoxia but also possess remarkable synergistic treatment effects of starving therapy, oxidative therapy, and chemotherapy on cancer cells in vitro and in vivo. Furthermore, we developed a two-layer cascade logic gate based on GOx@NPs to perform intracellular logic operations with cancer endogenous inputs for biocomputing. This study provides a referential example to develop intelligent tumor microenvironment-responsive supramolecular nanosystems with the ability of logical computing for precision cancer diagnosis and synergistic therapy.

Graphical abstract: Tumor microenvironment-activatable boolean logic supramolecular nanotheranostics based on a pillar[6]arene for tumor hypoxia imaging and multimodal synergistic therapy

Supplementary files

Article information

Article type
Research Article
Submitted
16 mrt 2021
Accepted
07 jun 2021
First published
09 jun 2021

Mater. Chem. Front., 2021,5, 5846-5856

Tumor microenvironment-activatable boolean logic supramolecular nanotheranostics based on a pillar[6]arene for tumor hypoxia imaging and multimodal synergistic therapy

X. Liu, C. Meng, G. Ji, J. Liu, P. Zhu, J. Qian, S. Zhu, Y. Zhang and Y. Ling, Mater. Chem. Front., 2021, 5, 5846 DOI: 10.1039/D1QM00411E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements