Issue 15, 2021

Biofilm inhibition in oral pathogens by nanodiamonds

Abstract

Complex microbial communities, e.g., biofilms residing in our oral cavity, have recognized clinical significance, as they are typically the main cause for infections. Particularly, they show high resistance to conventional antibiotics, and alternatives including nanotechnology are being intensively explored nowadays to provide more efficient therapeutics. Diamond nanoparticles, namely, nanodiamonds (NDs) with many promising physico-chemical properties, have been demonstrated to work as an effective antibacterial agent against planktonic cells (free-floating state). However, little is known about the behaviors of NDs against biofilms (sessile state). In this study, we uncovered their role in inhibiting biofilm formation and their disrupting effect on preformed biofilms in several selected orally and systemically important organisms. The current findings will advance the mechanistic understanding of NDs on oral pathogens and might accelerate corresponding clinical translation.

Graphical abstract: Biofilm inhibition in oral pathogens by nanodiamonds

Supplementary files

Article information

Article type
Communication
Submitted
18 apr 2021
Accepted
23 apr 2021
First published
26 apr 2021

Biomater. Sci., 2021,9, 5127-5135

Biofilm inhibition in oral pathogens by nanodiamonds

T. Zhang, S. Kalimuthu, V. Rajasekar, F. Xu, Y. C. Yiu, T. K. C. Hui, P. Neelakantan and Z. Chu, Biomater. Sci., 2021, 9, 5127 DOI: 10.1039/D1BM00608H

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