Issue 29, 2020

GS-5734: a potentially approved drug by FDA against SARS-Cov-2

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. COVID-19 is an ongoing global health crisis. Efficacious drugs against COVID-19 are not yet available. Therefore, rapid discovery of safe and efficacious agents against SARS-CoV-2 are needed urgently. Nucleoside analogs have an integral role in the treatment of viral infections. Owing to their broad-spectrum antiviral activities, C-nucleoside analogs have become key components of COVID-19 treatment regimens. Here, we review the state-of-the-art C-nucleoside GS-5734 (remdesivir) that is in preclinical research for COVID-19 treatment. As a potentially approved drug by the FDA against SARS-Cov-2 infection, the efficacy and safety of GS-5734 have been documented repeatedly in vitro, in animal models, and in humans. To better understand the drug-development process, this review focused on the discovery process, preparation methods, broad-spectrum activities, and antiviral mechanism of GS-5734.

Graphical abstract: GS-5734: a potentially approved drug by FDA against SARS-Cov-2

Article information

Article type
Perspective
Submitted
28 mei 2020
Accepted
29 jun 2020
First published
01 jul 2020

New J. Chem., 2020,44, 12417-12429

GS-5734: a potentially approved drug by FDA against SARS-Cov-2

Z. Wang and L. Yang, New J. Chem., 2020, 44, 12417 DOI: 10.1039/D0NJ02656E

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