Issue 6, 2018

Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions

Abstract

Dirhodium(II)-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp3)–H amination and alkene aziridination reactions, the latter followed by a nucleophilic aziridine ring opening, are the key steps of this strategy.

Graphical abstract: Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions

Supplementary files

Article information

Article type
Research Article
Submitted
27 sep 2017
Accepted
14 dec 2017
First published
21 dec 2017

Org. Chem. Front., 2018,5, 948-953

Approach to pactamycin analogues using rhodium(II)-catalyzed alkene aziridination and C(sp3)–H amination reactions

R. Rodrigues, Y. Lazib, J. Maury, L. Neuville, D. Leboeuf, P. Dauban and B. Darses, Org. Chem. Front., 2018, 5, 948 DOI: 10.1039/C7QO00878C

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