Issue 50, 2018

Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates

Abstract

Non-symmetric 1,3-substituted imidazopyridin-2-ones are a common structural scaffold found among many biologically active molecules. Herein we report an efficient, mild, and transition-metal free C–H amidation strategy to access such a pyrido-fused cyclic urea framework in good yields and with a broad functional group tolerance.

Graphical abstract: Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates

Supplementary files

Article information

Article type
Communication
Submitted
26 mrt 2018
Accepted
25 mei 2018
First published
31 mei 2018

Chem. Commun., 2018,54, 6935-6938

Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates

K. N. Lee, D. N. Spiegowski, J. W. Lee, S. Lim, F. Zhao and M. Ngai, Chem. Commun., 2018, 54, 6935 DOI: 10.1039/C8CC02425A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements