Issue 54, 2016

AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

Abstract

An inexpensive, practical and one-pot method has been developed for the synthesis of quinoxalines fused with pyrano[3,4-b]indole, the central core of Lamellarin D. The methodology involved construction of the central pyranone ring via an AlCl3-mediated heteroarylation-cyclization method. A number of compounds were prepared using this methodology, some of which were converted to the corresponding indol-3-ylquinoxaline derivatives. Several of the pyrano[3,4-b]indole fused quinoxalines showed promising growth inhibition of cervical and lung cancer cells and good interactions with topoisomerase I in silico.

Graphical abstract: AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

Supplementary files

Article information

Article type
Communication
Submitted
22 mrt 2016
Accepted
08 mei 2016
First published
10 mei 2016

RSC Adv., 2016,6, 48324-48328

AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

K. S. Kumar, S. R. Meesa, B. Rajesham, B. Bhasker, M. A. Ashfaq, A. A. Khan, S. S. Rao and M. Pal, RSC Adv., 2016, 6, 48324 DOI: 10.1039/C6RA07507J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements