Issue 5, 2016

Assembly of hepatitis E vaccine by ‘in situ’ growth of gold clusters as nano-adjuvants: an efficient way to enhance the immune responses of vaccination

Abstract

Vaccine-based immunotherapy plays an integral role in the development of present and future clinical therapies. Despite the success, there is still a great need to improve the efficiency and safety of vaccines. Nanoparticles have been widely used for improving the efficacy of vaccines by encapsulating the vaccines or using nanoparticles as immune adjuvants. However, the methods for the preparation of nanoparticles are complex with a relatively low encapsulation efficiency of protein vaccine inside the nanocarriers and/or undefined physiochemical properties. Here, we report a new method of preparation of a vaccine by the “in situ” growth of gold clusters in the hepatitis E vaccine (HEVA). The gold cluster grafted HEVA (HEVA/Au) can be easily obtained and there is no loss of HEVA during the preparation process. More importantly, the “in situ” prepared HEVA/Au can not only enhance its immune responses in vivo, but also reduce the potential toxicity of HEVA. Furthermore, the intrinsic fluorescence of gold clusters enables the HEVA to be traceable, which may open a way to track the dynamic behavior of vaccines and further help to optimize an individual therapeutic regimen for immunotherapy.

Graphical abstract: Assembly of hepatitis E vaccine by ‘in situ’ growth of gold clusters as nano-adjuvants: an efficient way to enhance the immune responses of vaccination

Supplementary files

Article information

Article type
Communication
Submitted
12 mei 2016
Accepted
17 jun 2016
First published
17 jun 2016

Nanoscale Horiz., 2016,1, 394-398

Assembly of hepatitis E vaccine by ‘in situ’ growth of gold clusters as nano-adjuvants: an efficient way to enhance the immune responses of vaccination

H. Wang, Y. Ding, S. Su, D. Meng, A. Mujeeb, Y. Wu and G. Nie, Nanoscale Horiz., 2016, 1, 394 DOI: 10.1039/C6NH00087H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements