Issue 5, 2015

Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

Abstract

The initial step of a Pd-catalysed phosphine-free direct arylation reaction was investigated to provide mechanistic insight, leading to optimisation of the catalytic reaction. On the basis of our observations, the amount of the Pd(OAc)2 catalyst was reduced to 1 mol%, affording a good yield of the desired product in combination with a reduction in the amount of by-products.

Graphical abstract: Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

Supplementary files

Article information

Article type
Research Article
Submitted
28 dec 2014
Accepted
10 mrt 2015
First published
18 mrt 2015

Org. Chem. Front., 2015,2, 520-525

Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

J. Kuwabara, M. Sakai, Q. Zhang and T. Kanbara, Org. Chem. Front., 2015, 2, 520 DOI: 10.1039/C4QO00351A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements