Issue 38, 2009

The concise synthesis of chiral tfb ligands and their application to the rhodium-catalyzed asymmetric arylation of aldehydes

Abstract

New C2-symmetric tetrafluorobenzobarrelene ligands were prepared and applied successfully to the rhodium-catalyzed asymmetric addition of arylboronic acids to aromaticaldehydes giving chiral diarylmethanols in high yield with high enantioselectivity.

Graphical abstract: The concise synthesis of chiral tfb ligands and their application to the rhodium-catalyzed asymmetric arylation of aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
05 jun 2009
Accepted
27 jul 2009
First published
17 aug 2009

Chem. Commun., 2009, 5713-5715

The concise synthesis of chiral tfb ligands and their application to the rhodium-catalyzed asymmetric arylation of aldehydes

T. Nishimura, H. Kumamoto, M. Nagaosa and T. Hayashi, Chem. Commun., 2009, 5713 DOI: 10.1039/B911118B

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