Issue 19, 2024

Therapeutic coordination polymers: tailoring drug release through metal–ligand interactions

Abstract

Developing tunable materials which exhibit sustained drug release is a considerable challenge. Herein, we report the concept of Therapeutic Coordination Polymers (TCPs); non-porous coordination polymers constructed from biocompatible components which demonstrate tunable zero-order drug release kinetics upon degradation of metal–ligand bonds. TCPs were constructed from three principal components: (i) a cationic metal center (M = Mg2+, Mn2+, Zn2+, or Cu2+); (ii) an anionic drug (Diclofenac); and (iii) an alkyl bis-imidazole organic ligand which behaves as a “linker” between metal centers. Most drug-release materials, such as amorphous polymer dispersions, or metal–organic frameworks rely on a diffusion-based mechanism for drug release, but the degradation-controlled release of drugs from non-porous one-periodic coordination polymers has been largely unexplored. TCPs described herein exhibit a high wt% of pharmaceutical (>62%), tailorable zero-order drug release rate kinetics which span over three orders of magnitude, and stimuli-responsive drug release behavior making them well suited for extended drug-release applications.

Graphical abstract: Therapeutic coordination polymers: tailoring drug release through metal–ligand interactions

Supplementary files

Article information

Article type
Edge Article
Submitted
30 jan 2024
Accepted
10 apr 2024
First published
11 apr 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2024,15, 7041-7050

Therapeutic coordination polymers: tailoring drug release through metal–ligand interactions

J. N. Murphy, J. Kobti, M. Dao, D. Wear, M. Okoko, S. Pandey and V. N. Vukotic, Chem. Sci., 2024, 15, 7041 DOI: 10.1039/D4SC00732H

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