Issue 2, 2024

A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy

Abstract

A light-responsive polymer allowing the controlled release of camptothecin and the generation of reactive oxygen species (ROS) is reported. The polymer was prepared by controlled copolymerisation of water-soluble N,N-dimethyl acrylamide with a bromocoumarin methacrylate monomer. The lipophilic chemotherapy agent camptothecin was caged onto the coumarin unit via a photo-cleavable carbonate ester enabling light-triggered cargo release. The polymer showed good biocompatibility in the dark, and high cancer cell killing activity mediated both by the photo-release of camptothecin and ROS generation.

Graphical abstract: A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
12 okt 2023
Accepted
04 dec 2023
First published
05 dec 2023
This article is Open Access
Creative Commons BY license

Polym. Chem., 2024,15, 54-58

A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy

P. A. Shaw, M. Klausen and M. Bradley, Polym. Chem., 2024, 15, 54 DOI: 10.1039/D3PY01137B

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