Issue 2, 2024

Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation

Abstract

Phase-separated liposomes were used to formulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a protein that selectively kills cancer cells while sparing most healthy ones. By controlling the average number of TRAIL molecules per liposome, we demonstrate the ability to tune the formation of TRAIL clusters and their resulting apoptotic activity.

Graphical abstract: Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation

Supplementary files

Article information

Article type
Communication
Submitted
01 okt 2023
Accepted
21 dec 2023
First published
29 dec 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2024,6, 402-405

Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation

Z. Zhang and M. R. King, Nanoscale Adv., 2024, 6, 402 DOI: 10.1039/D3NA00841J

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