Issue 5, 2024

Progress in developing microphysiological systems for biological product assessment

Abstract

Microphysiological systems (MPS), also known as miniaturized physiological environments, have been engineered to create and study functional tissue units capable of replicating organ-level responses in specific contexts. The MPS has the potential to provide insights about the safety, characterization, and effectiveness of medical products that are different and complementary to insights gained from traditional testing systems, which can help facilitate the transition of potential medical products from preclinical phases to clinical trials, and eventually to market. While many MPS are versatile and can be used in various applications, most of the current applications have primarily focused on drug discovery and testing. Yet, there is a limited amount of research available that demonstrates the use of MPS in assessing biological products such as cellular and gene therapies. This review paper aims to address this gap by discussing recent technical advancements in MPS and their potential for assessing biological products. We further discuss the challenges and considerations involved in successful translation of MPS into mainstream product testing.

Graphical abstract: Progress in developing microphysiological systems for biological product assessment

Article information

Article type
Critical Review
Submitted
13 okt 2023
Accepted
26 dec 2023
First published
17 jan 2024
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2024,24, 1293-1306

Progress in developing microphysiological systems for biological product assessment

M. Mansouri, J. Lam and K. E. Sung, Lab Chip, 2024, 24, 1293 DOI: 10.1039/D3LC00876B

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