Issue 5, 2024

Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities

Abstract

Microfluidic technologies are revolutionizing the synthesis of nanoscale lipid particles and enabling new opportunities for the production of lipid-based nanomedicines. By harnessing the benefits of microfluidics for controlling diffusive and advective transport within microfabricated flow cells, microfluidic platforms enable unique capabilities for lipid nanoparticle synthesis with precise and tunable control over nanoparticle properties. Here we present an assessment of the current state of microfluidic technologies for lipid-based nanoparticle and nanomedicine production. Microfluidic techniques are discussed in the context of conventional production methods, with an emphasis on the capabilities of microfluidic systems for controlling nanoparticle size and size distribution. Challenges and opportunities associated with the scaling of manufacturing throughput are discussed, together with an overview of emerging microfluidic methods for lipid nanomedicine post-processing. The impact of additive manufacturing on current and future microfluidic platforms is also considered.

Graphical abstract: Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities

Article information

Article type
Critical Review
Submitted
28 sep 2023
Accepted
07 dec 2023
First published
02 jan 2024

Lab Chip, 2024,24, 1154-1174

Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities

S. Mehraji and D. L. DeVoe, Lab Chip, 2024, 24, 1154 DOI: 10.1039/D3LC00821E

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