Issue 6, 2023

Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Abstract

Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

Graphical abstract: Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Supplementary files

Article information

Article type
Communication
Submitted
20 feb 2023
Accepted
08 mrt 2023
First published
15 mrt 2023
This article is Open Access
Creative Commons BY license

Nanoscale Horiz., 2023,8, 776-782

Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

G. Biagiotti, G. Toniolo, M. Albino, M. Severi, P. Andreozzi, M. Marelli, H. Kokot, G. Tria, A. Guerri, C. Sangregorio, J. Rojo, D. Berti, M. Marradi, S. Cicchi, I. Urbančič, Y. van Kooyk, F. Chiodo and B. Richichi, Nanoscale Horiz., 2023, 8, 776 DOI: 10.1039/D3NH00063J

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