Issue 5, 2023

Recent advances in microfluidics-based bioNMR analysis

Abstract

Nuclear magnetic resonance (NMR) has been used in a variety of fields due to its powerful analytical capability. To facilitate biochemical NMR (bioNMR) analysis for samples with a limited mass, a number of integrated systems have been developed by coupling microfluidics and NMR. However, there are few review papers that summarize the recent advances in the development of microfluidics-based NMR (μNMR) systems. Herein, we review the advancements in μNMR systems built on high-field commercial instruments and low-field compact platforms. Specifically, μNMR platforms with three types of typical microcoils settled in the high-field NMR instruments will be discussed, followed by summarizing compact NMR systems and their applications in biomedical point-of-care testing. Finally, a conclusion and future prospects in the field of μNMR were given.

Graphical abstract: Recent advances in microfluidics-based bioNMR analysis

Article information

Article type
Critical Review
Submitted
22 sep 2022
Accepted
01 dec 2022
First published
18 jan 2023

Lab Chip, 2023,23, 1213-1225

Recent advances in microfluidics-based bioNMR analysis

Z. Li, Q. Bao, C. Liu, Y. Li, Y. Yang and M. Liu, Lab Chip, 2023, 23, 1213 DOI: 10.1039/D2LC00876A

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