Issue 27, 2023

Synthesis, structure diversity, and antimicrobial studies of Ag(i) complexes with quinoline-type ligands

Abstract

Compounds [Ag(5NO2Qu)2]BF4 (1) and [Ag(Qu3CN)(H2O)]BF4 (2) were prepared and studied from a structural perspective and screened for antimicrobial activity. The Ag(I) in the monomeric complex 1 is coordinated to two 5-nitroquinoline (5NO2Qu) ligands via the N-atoms of the quinoline rings with equidistant Ag–N bonds (2.146(2) Å) and a N–Ag–N# bond angle of 171.42(8)°. The 2D coordination polymer 2 contains tetracoordinated Ag(I) with two N-atoms (N1 and N2#1) from two quinoline-3-carbonitrile (Qu3CN) ligands and two O-atoms (O1 and O1#1) from two water molecules. The Qu3CN ligand acts as a connector between the Ag(I) sites along the b-direction via two short Ag1–N1 (2.185(4) Å) and Ag1–N2#1 (2.204(4) Å) bonds. In addition, the Ag(I) is coordinated with two symmetry related water molecules which are also acting as connectors between the Ag(I) sites along the a-direction via two longer Ag1–O1 (2.470(4) Å) and Ag1–O1#2 (2.546(4) Å) bonds. Hirshfeld surface analysis confirmed the significance of the polar F⋯H contacts in the molecular packing of 1 (25.9%) and 2 (39.9%). In addition, the crystal packing of 1 showed a significant amount of polar O⋯H (23.5%) contacts. Also, both complexes displayed π–π stacking interactions. The Ag(I) complexes and the free ligand were assessed for their antimicrobial activities. It was found that 1 (MIC = 7.8 μg mL−1) and 2 (MIC = 31.25 μg mL−1) have higher antifungal potency against C. albicans than their free ligands (MIC = 125 μg mL−1). Interestingly, 1 has better antifungal activity than the standard nystatin (15.6 μg mL−1). Also, both Ag(I) complexes and the free ligands as well have better activity against P. mirabilis than the common antibiotic amoxicillin.

Graphical abstract: Synthesis, structure diversity, and antimicrobial studies of Ag(i) complexes with quinoline-type ligands

Supplementary files

Article information

Article type
Paper
Submitted
24 apr 2023
Accepted
15 jun 2023
First published
16 jun 2023
This article is Open Access
Creative Commons BY license

CrystEngComm, 2023,25, 3922-3930

Synthesis, structure diversity, and antimicrobial studies of Ag(I) complexes with quinoline-type ligands

A. Yousri, M. Haukka, M. A. M. Abu-Youssef, M. Salah Ayoup, M. M. F. Ismail, N. G. El Menofy, S. M. Soliman, A. Barakat, F. M. Amombo Noa and L. Öhrström, CrystEngComm, 2023, 25, 3922 DOI: 10.1039/D3CE00417A

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