Issue 40, 2022

Early diagnostic imaging of pneumonia with an ultra-sensitive two-photon near-infrared fluorescent probe

Abstract

The mortality rate of pneumonia increases significantly with the prolongation of illness. In the pursuit of a tool to accurately diagnose pneumonia in its early stages, we designed and synthesized a two-photon near-infrared fluorescent probe (DCQN) to identify increased concentrations of the inflammation marker SO2. The probe was found to specifically react with SO2 by undergoing a 1,4-addition reaction to generate near-infrared fluorescence with good sensitivity (6 s), a large Stokes shift (110 nm) and low detection limit (1.49 nM). DCQN has near-infrared emission as well as good two-photon performance, which can image exogenous and endogenous SO2 in cells and avoid interference from background fluorescence from cells. Furthermore, this study achieved accurate imaging of a pneumonia lesion site in deep tissues to provide a tool for the fluorescence diagnostic imaging of pneumonia in situ.

Graphical abstract: Early diagnostic imaging of pneumonia with an ultra-sensitive two-photon near-infrared fluorescent probe

Supplementary files

Article information

Article type
Paper
Submitted
09 aug 2022
Accepted
08 sep 2022
First published
28 sep 2022

J. Mater. Chem. B, 2022,10, 8186-8192

Early diagnostic imaging of pneumonia with an ultra-sensitive two-photon near-infrared fluorescent probe

E. Song, Y. Lai, H. Lu, Y. Tang, L. Zeng and W. Lin, J. Mater. Chem. B, 2022, 10, 8186 DOI: 10.1039/D2TB01687G

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