Issue 8, 2022

Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction

Abstract

SERS spectroscopy, a nontraditional chiral analysis tool, is used to discriminate between D- and L-phenylalanine (Phe), with the Raman scattering enhancement degree of D-Phe being 50-fold greater than that of L-Phe. Such discrimination is achieved by chiral interactions between Phe and the chiral drug molecule of sertraline on silver coated gold nanorods.

Graphical abstract: Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction

Supplementary files

Article information

Article type
Communication
Submitted
10 feb 2022
Accepted
09 mrt 2022
First published
10 mrt 2022

Analyst, 2022,147, 1540-1543

Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction

Y. He, Q. Zhou, N. Wang, H. Yang and X. Liu, Analyst, 2022, 147, 1540 DOI: 10.1039/D2AN00246A

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