Issue 47, 2021

Cyclodextrins: promising scaffolds for MRI contrast agents

Abstract

Magnetic resonance imaging (MRI) is a powerful tool for non-invasive, high-resolution three-dimensional medical imaging of anatomical structures such as organs and tissues. The use of contrast agents based on gadolinium chelates started in 1988 to improve the quality of the image, since researchers and industry focused their attention on the development of more efficient and stable structures. This review is about the state of the art of MRI contrast agents based on cyclodextrin scaffolds. Chemical engineering strategies are herein reported including host–guest inclusion complexation and covalent linkages. It also offers descriptions of the MRI properties and in vitro and in vivo biomedical applications of these emerging macrostructures. It highlights that these supramolecular associations can improve the image contrast, the sensitivity, and the efficiency of MRI diagnosis by targeting cancer tumors and other diseases with success proving the great potential of this natural macrocycle.

Graphical abstract: Cyclodextrins: promising scaffolds for MRI contrast agents

Article information

Article type
Review Article
Submitted
25 mei 2021
Accepted
24 aug 2021
First published
17 sep 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 29762-29785

Cyclodextrins: promising scaffolds for MRI contrast agents

B. S. Sembo-Backonly, F. Estour and G. Gouhier, RSC Adv., 2021, 11, 29762 DOI: 10.1039/D1RA04084G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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