Issue 11, 2021

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

Abstract

Bioactive carbon dots (C-dots) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the “light-up” behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune therapy agent for melanoma skin cancer.

Graphical abstract: From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

Supplementary files

Article information

Article type
Paper
Submitted
27 dec 2020
Accepted
18 jan 2021
First published
03 feb 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 6346-6352

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

F. H. Horst, C. V. D. S. Rodrigues, P. H. P. R. Carvalho, A. M. Leite, R. B. Azevedo, B. A. D. Neto, J. R. Corrêa, M. P. Garcia, S. Alotaibi, M. Henini, S. B. Chaves and M. O. Rodrigues, RSC Adv., 2021, 11, 6346 DOI: 10.1039/D0RA10859F

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