Issue 15, 2021

Asymmetric small organic molecule-based NIR-II fluorophores for high performance tumor phototheranostics

Abstract

Small organic molecules hold great promise for phototheranostics due to their well-defined chemical structures and optical properties, excellent biodegradation and biocompatibility, high purity, and outstanding repeatability. Nevertheless, numerous small molecules exhibited weak absorption in the near-infrared I (NIR-I) region (particularly 808 nm, the optimal tissue transparent window in the NIR-I region), expedient NIR-I fluorescence emission, and single-mode therapy, which greatly hinder their phototheranostic performances. Herein, versatile nanoparticle DTPT NPs based on a single-component asymmetric small organic molecule were successfully constructed as a proof-of-concept example for high-performance phototheranostics. The developed DTPT NPs possessed strong absorption at 808 nm, excellent near-infrared II (NIR-II) fluorescence emission, prominent reactive oxygen species, and hyperthermia production ability (photothermal conversion efficiency was as high as 61.6%). Furthermore, upon a single 808 nm laser irradiation, the tumor inhibition rate of the versatile DTPT NPs was demonstrated to be 90.8%, profiting from the satisfactory NIR-II fluorescence imaging and photothermal/photodynamic performances. Moreover, the NPs showed superb safety to normal tissues, further demonstrating the potential application of NPs in clinical practice. This study provides an idea to construct small molecule-based nanoplatforms for high performance phototheranostics.

Graphical abstract: Asymmetric small organic molecule-based NIR-II fluorophores for high performance tumor phototheranostics

Supplementary files

Article information

Article type
Research Article
Submitted
25 mrt 2021
Accepted
26 mei 2021
First published
02 jun 2021

Mater. Chem. Front., 2021,5, 5689-5697

Asymmetric small organic molecule-based NIR-II fluorophores for high performance tumor phototheranostics

Q. Wang, X. Niu, L. Yang, J. Liu, J. Wang, X. Xu, W. Tang, W. Huang and Q. Fan, Mater. Chem. Front., 2021, 5, 5689 DOI: 10.1039/D1QM00472G

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