Issue 31, 2021

New antimicrobial self-assembling short lipopeptides

Abstract

Lipopeptides are an exceptional example of amphiphilic molecules that self-assemble into functional structures with applications in the areas of nanotechnology, catalysis or medicinal chemistry. Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization and antimicrobial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.

Graphical abstract: New antimicrobial self-assembling short lipopeptides

Supplementary files

Article information

Article type
Communication
Submitted
24 jun 2021
Accepted
16 jul 2021
First published
16 jul 2021
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2021,19, 6797-6803

New antimicrobial self-assembling short lipopeptides

C. Vicente-García and I. Colomer, Org. Biomol. Chem., 2021, 19, 6797 DOI: 10.1039/D1OB01227D

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