Issue 48, 2021

Structure determination of small molecule compounds by an electron diffractometer for 3D ED/MicroED

Abstract

3D electron diffraction (3D ED)/Micro electron diffraction (MicroED) has extended the limits of crystallography by enabling the determination of three dimensional molecular structures from sub-μm microcrystals. However, 3D ED/microED measurements using current state-of-the-art electron microscopes require experts in both electron microscopy and crystallography making the method rather difficult for researchers who simply need structures. Here, we present a diffractometer specifically designed for 3D ED/microED and show how it works for determining crystal structures. The newly developed electron diffractometer will provide many researchers with an easy path to structure determination of crystals that are less than 1 μm in size.

Graphical abstract: Structure determination of small molecule compounds by an electron diffractometer for 3D ED/MicroED

Supplementary files

Article information

Article type
Paper
Submitted
31 aug 2021
Accepted
26 okt 2021
First published
19 nov 2021
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2021,23, 8622-8630

Structure determination of small molecule compounds by an electron diffractometer for 3D ED/MicroED

S. Ito, F. J. White, E. Okunishi, Y. Aoyama, A. Yamano, H. Sato, J. D. Ferrara, M. Jasnowski and M. Meyer, CrystEngComm, 2021, 23, 8622 DOI: 10.1039/D1CE01172C

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