Issue 98, 2021

Oxide nanowire microfluidics addressing previously-unattainable analytical methods for biomolecules towards liquid biopsy

Abstract

Nanowire microfluidics using a combination of self-assembly and nanofabrication technologies is expected to be applied to various fields due to its unique properties. We have been working on the fabrication of nanowire microfluidic devices and the development of analytical methods for biomolecules using the unique phenomena generated by the devices. The results of our research are not just limited to the development of nanospace control with “targeted dimensions” in “targeted arrangements” with “targeted materials/surfaces” in “targeted spatial locations/structures” in microfluidic channels, but also cover a wide range of analytical methods for biomolecules (extraction, separation/isolation, and detection) that are impossible to achieve with conventional technologies. Specifically, we are working on the extraction technology “the cancer-related microRNA extraction method in urine,” the separation technology “the ultrafast and non-equilibrium separation method for biomolecules,” and the detection technology “the highly sensitive electrical measurement method.” These research studies are not just limited to the development of biomolecule analysis technology using nanotechnology, but are also opening up a new academic field in analytical chemistry that may lead to the discovery of new pretreatment, separation, and detection principles.

Graphical abstract: Oxide nanowire microfluidics addressing previously-unattainable analytical methods for biomolecules towards liquid biopsy

Article information

Article type
Feature Article
Submitted
10 sep 2021
Accepted
15 okt 2021
First published
26 nov 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 13234-13245

Oxide nanowire microfluidics addressing previously-unattainable analytical methods for biomolecules towards liquid biopsy

H. Takahashi, Y. Baba and T. Yasui, Chem. Commun., 2021, 57, 13234 DOI: 10.1039/D1CC05096F

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