Issue 1, 2020

A hybrid polymer to target blood group dependence of cholera toxin

Abstract

Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the cholera toxin in the intestine. However, increasing evidence is pointing towards the role of fucosylated conjugates as additional attachment options of the toxin. In the present paper we have synthesized a polymeric hybrid which can inhibit both modes of attachment.

Graphical abstract: A hybrid polymer to target blood group dependence of cholera toxin

Supplementary files

Article information

Article type
Communication
Submitted
01 nov 2019
Accepted
28 nov 2019
First published
28 nov 2019
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2020,18, 52-55

A hybrid polymer to target blood group dependence of cholera toxin

D. Haksar, L. Quarles van Ufford and R. J. Pieters, Org. Biomol. Chem., 2020, 18, 52 DOI: 10.1039/C9OB02369K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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