Issue 13, 2020

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

Abstract

The study reported here concerns the preparation of a novel graphene-diaminotriazine (G-DAT) nanocomposite hydrogel for application in the drug delivery field. The hybrid nature of this material is founded on two key elements: the presence of the DAT backbone induced the formation of hydrophobic regions that allowed efficient loading of a series of drugs of increasing hydrophobicity (Metronidazole, Benzocaine, Ibuprofen, Naproxen and Imipramine), while simultaneously endowing swelling-induced pH-responsiveness to the hydrogel. Additionally, the incorporation of graphene was found to interfere with these hydrophobic domains through favourable non-covalent interactions, thus leading to the partial disruption of these aggregates. As a consequence, graphene facilitated and enhanced the release of model hydrophobic drug Imipramine in a synergistic manner with the pH trigger, and increased the swelling capacities and improved mechanical performance. This hybrid hydrogel can therefore be envisaged as a proof-of-concept system for the release of hydrophobic compounds in the field of drug delivery.

Graphical abstract: Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

Supplementary files

Article information

Article type
Paper
Submitted
14 dec 2019
Accepted
26 feb 2020
First published
18 mrt 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2020,12, 7072-7081

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

J. Leganés, A. Sánchez-Migallón, S. Merino and E. Vázquez, Nanoscale, 2020, 12, 7072 DOI: 10.1039/C9NR10588C

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