Issue 46, 2018

A novel label-free photoelectrochemical immunosensor based on NCQDs and Bi2S3 co-sensitized hierarchical mesoporous SnO2 microflowers for detection of NT-proBNP

Abstract

A unique hierarchical mesoporous SnO2 microflower was utilized for the fabrication of an immunosensor. The modified nitrogen-doped carbon quantum dots (NCQDs) improved the photoelectrochemical (PEC) activity of the SnO2, and contributed to the in situ assembly of Bi2S3 nanoparticles on the surface of the SnO2 materials. Under the stimulation of visible light and ascorbic acid as an efficient electron donor, the NCQDs and Bi2S3 co-sensitized mesoporous SnO2 microflower (SnO2/NCQDs/Bi2S3) modified ITO electrode exhibited an excellent photoelectric signal arriving at around 150 μA. Moreover, a novel label-free PEC sensor based SnO2/NCQDs/Bi2S3 composite was constructed, which enabled the ultrasensitive detection of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The photocurrents decreased linearly with the logarithm of NT-proBNP concentration in the range of 0.01–50 ng mL−1 with a detection limit of 3.7 pg mL−1 (S/N = 3). Furthermore, the novel PEC immunosensor showed perfect selectivity, good stability and reproducibility, which suggest promising applications in the sensing and clinical diagnosis of cardiac disease.

Graphical abstract: A novel label-free photoelectrochemical immunosensor based on NCQDs and Bi2S3 co-sensitized hierarchical mesoporous SnO2 microflowers for detection of NT-proBNP

Supplementary files

Article information

Article type
Paper
Submitted
12 aug 2018
Accepted
12 okt 2018
First published
15 okt 2018

J. Mater. Chem. B, 2018,6, 7634-7642

A novel label-free photoelectrochemical immunosensor based on NCQDs and Bi2S3 co-sensitized hierarchical mesoporous SnO2 microflowers for detection of NT-proBNP

D. Fan, C. Bao, X. Liu, D. Wu, Y. Zhang, H. Wang, B. Du and Q. Wei, J. Mater. Chem. B, 2018, 6, 7634 DOI: 10.1039/C8TB02122H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements