Issue 7, 2018

Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites

Abstract

An organocatalytic enantioselective 1,4-addition of phosphites to azadienes has been successfully developed using quinine as a catalyst, providing an efficient and facile route to optically active γ-aminophosphonates with up to 94% ee.

Graphical abstract: Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites

Supplementary files

Article information

Article type
Research Article
Submitted
27 dec 2017
Accepted
27 jan 2018
First published
29 jan 2018

Org. Chem. Front., 2018,5, 1148-1151

Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites

Z. Gu, J. Zhou, G. Jiang and Y. Zhou, Org. Chem. Front., 2018, 5, 1148 DOI: 10.1039/C7QO01158J

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