Issue 7, 2018

nBu4NOTf-promoted radical self-hydrogen transferring isomerization under transition metal-free conditions

Abstract

We report the first allylic isomerization of alcohols catalyzed by nBu4NOTf generated in situ from tetrabutylammonium triflate and potassium tert-butoxide. Substituted ketones could be prepared under mild conditions in good to excellent yields. The relationship between catalysts and their reactivity has been investigated by systematic kinetic studies. The radical nature of this isomerization reaction has also been confirmed.

Graphical abstract: n Bu4NOTf-promoted radical self-hydrogen transferring isomerization under transition metal-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
20 dec 2017
Accepted
31 jan 2018
First published
01 feb 2018

Org. Chem. Front., 2018,5, 1213-1216

n Bu4NOTf-promoted radical self-hydrogen transferring isomerization under transition metal-free conditions

H. Zheng, C. Yao, J. Qu and Y. Kang, Org. Chem. Front., 2018, 5, 1213 DOI: 10.1039/C7QO01138E

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