Issue 2, 2018

Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation

Abstract

A Pd(II)-catalyzed regioselective C5 alkenylation of 2-acylpyrroles has been developed employing 3-nitrile benzoyl group (N-(3-NCC6H4CO-)) as an efficient N-protecting group. The protocol provided a simple and efficient method to synthesize C5-alkenylated 2-acylpyrrole derivatives. The employed N-protecting group was readily removable in the presence of HCl/EtOH under mild conditions.

Graphical abstract: Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation

Supplementary files

Article information

Article type
Research Article
Submitted
17 aug 2017
Accepted
30 sep 2017
First published
09 okt 2017

Org. Chem. Front., 2018,5, 162-165

Regioselective C5 alkenylation of 2-acylpyrroles via Pd(II)-catalyzed C–H bond activation

J. Duan, R. Mi, J. Sun and M. Zhou, Org. Chem. Front., 2018, 5, 162 DOI: 10.1039/C7QO00732A

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