Issue 39, 2018

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Abstract

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.

Graphical abstract: Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Supplementary files

Article information

Article type
Communication
Submitted
28 apr 2018
Accepted
09 aug 2018
First published
09 aug 2018

CrystEngComm, 2018,20, 5945-5948

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

F. Wang, Q. Zhang, Z. Zhang, X. Gong, J. Wang and X. Mei, CrystEngComm, 2018, 20, 5945 DOI: 10.1039/C8CE00689J

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