Issue 31, 2017

Bioactive glasses in wound healing: hope or hype?

Abstract

Bioactive glasses have long been investigated in mineralized tissue regeneration, but recently their potential applications in soft tissue repair, and in particular wound healing, have demonstrated great promise. Commonly used glasses, such as the silicate-based Bioglass® 45S5 [(46.1)SiO2–(26.9)CaO–(24.4)Na2O–(2.6)P2O5 (mol%)] and borate-based 13-93B3 [(54)B2O3–(22)CaO–(6)Na2O–(8)K2O–(8)MgO–(2)P2O5 (mol%)] have been implicated in the stages of wound healing due to their ability to release ions that can stimulate processes, such as haemostasis, antibacterial efficacy, epithelial cell migration, angiogenesis, and fibroblastic cell proliferation, amongst others. More recently, a wound dressing composed of a borate-based glass received regulatory approval for use in the treatment of acute and chronic wounds. However, to date, there are no comprehensive reports on their specific mechanism of action in accelerating the wound healing processes. In this highlight, we will provide a brief overview of the wound healing stages, review the bioactive glass formulations that have been investigated for potential applications in wound healing and attempt to summarize the consensus on why these glasses may be successful in wound healing.

Graphical abstract: Bioactive glasses in wound healing: hope or hype?

Article information

Article type
Highlight
Submitted
04 mei 2017
Accepted
18 jul 2017
First published
18 jul 2017

J. Mater. Chem. B, 2017,5, 6167-6174

Bioactive glasses in wound healing: hope or hype?

S. Naseri, W. C. Lepry and S. N. Nazhat, J. Mater. Chem. B, 2017, 5, 6167 DOI: 10.1039/C7TB01221G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements