Issue 6, 2017

(1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

Abstract

A family of easily scalable, shelf-stable, optically pure reagents (1S)-(−)-N-trifluoromethylthio-2,10-camphorsultam 1a–c was successfully developed. In particular, compound 1c was shown to be an efficient reagent that is capable of transferring chirality to other prochiral nucleophiles such as β-ketoesters, oxindoles and benzofuranones with good to excellent enantioselectivities.

Graphical abstract: (1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

Supplementary files

Article information

Article type
Research Article
Submitted
16 jan 2017
Accepted
09 feb 2017
First published
10 feb 2017
This article is Open Access
Creative Commons BY-NC license

Org. Chem. Front., 2017,4, 1051-1057

(1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

H. Zhang, X. Leng, X. Wan and Q. Shen, Org. Chem. Front., 2017, 4, 1051 DOI: 10.1039/C7QO00042A

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