Issue 1, 2017

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

Abstract

We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore amino-catalyzed reactions, including asymmetric iminium-catalyzed Friedel–Crafts alkylations in microflow and micro confined reaction vessels.

Graphical abstract: On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

Supplementary files

Article information

Article type
Communication
Submitted
28 sep 2016
Accepted
23 nov 2016
First published
23 nov 2016
This article is Open Access
Creative Commons BY license

Lab Chip, 2017,17, 76-81

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

J. J. Heiland, R. Warias, C. Lotter, L. Mauritz, P. J. W. Fuchs, S. Ohla, K. Zeitler and D. Belder, Lab Chip, 2017, 17, 76 DOI: 10.1039/C6LC01217E

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