Issue 10, 2017

Photoredox-catalysed redox-neutral trifluoromethylation of vinyl azides for the synthesis of α-trifluoromethylated ketones

Abstract

A redox-neutral, mild, and simple protocol is developed for the synthesis of α-trifluoromethylated ketones from vinyl azides under transition-metal-free conditions. In the presence of organic photoredox catalyst N-methyl-9-mesityl acridinium and sodium trifluoromethanesulfinate, a broad range of substituted vinyl azides were found to react smoothly upon visible-light irradiation, readily furnishing the corresponding products in satisfied yields.

Graphical abstract: Photoredox-catalysed redox-neutral trifluoromethylation of vinyl azides for the synthesis of α-trifluoromethylated ketones

Supplementary files

Article information

Article type
Communication
Submitted
17 dec 2016
Accepted
13 jan 2017
First published
13 jan 2017

Chem. Commun., 2017,53, 1696-1699

Photoredox-catalysed redox-neutral trifluoromethylation of vinyl azides for the synthesis of α-trifluoromethylated ketones

H. Qin, S. Wu, J. Liu and F. Liu, Chem. Commun., 2017, 53, 1696 DOI: 10.1039/C6CC10035J

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