Issue 6, 2017

Selective C–H trifluoromethylation of benzimidazoles through photoredox catalysis

Abstract

The protocol presented here is a new strategy for visible light induced C–H trifluoromethylation at C4 of benzimidazoles using Togni's reagent in the presence of fac-Ir(ppy)3. Its advantages are its operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated.

Graphical abstract: Selective C–H trifluoromethylation of benzimidazoles through photoredox catalysis

Supplementary files

Article information

Article type
Communication
Submitted
10 nov 2016
Accepted
11 dec 2016
First published
12 dec 2016

Chem. Commun., 2017,53, 1041-1044

Selective C–H trifluoromethylation of benzimidazoles through photoredox catalysis

G. Gao, C. Yang and W. Xia, Chem. Commun., 2017, 53, 1041 DOI: 10.1039/C6CC08975E

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