Issue 25, 2016

Long circulating reduced graphene oxide–iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

Abstract

Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron oxide nanoparticles (RGO–IONP–1stPEG–2ndPEG). The nanoconjugates exhibited a prolonged blood circulation half-life (∼27.7 h) and remarkable tumor accumulation (>11 %ID g−1) via an enhanced permeability and retention (EPR) effect. Due to the strong near-infrared absorbance and superparamagnetism of RGO–IONP–1stPEG–2ndPEG, multimodality imaging combining positron emission tomography (PET) imaging with magnetic resonance imaging (MRI) and photoacoustic (PA) imaging was successfully achieved. The promising results suggest the great potential of these nanoconjugates for multi-dimensional and more accurate tumor diagnosis and therapy in the future.

Graphical abstract: Long circulating reduced graphene oxide–iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

Article information

Article type
Paper
Submitted
24 dec 2015
Accepted
01 apr 2016
First published
06 apr 2016

Nanoscale, 2016,8, 12683-12692

Long circulating reduced graphene oxide–iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

C. Xu, S. Shi, L. Feng, F. Chen, S. A. Graves, E. B. Ehlerding, S. Goel, H. Sun, C. G. England, R. J. Nickles, Z. Liu, T. Wang and W. Cai, Nanoscale, 2016, 8, 12683 DOI: 10.1039/C5NR09193D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements