Issue 7, 2016

Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ1–42 with copper ions

Abstract

The molecular mechanism of CeONP in protecting against neuronal cytotoxicity from amyloid peptides and copper ions was investigated systematically by photoluminescence of [Ru(phen)2dppz]2+, morphology of TEM, mass spectroscopy, cell viability assay, ROS fluorescence assay, and EPR. The results revealed that CeONPs reduced Aβ1–42 aggregation, protected from neurotoxicity of ROS induced by Cu2+ + Aβ1–42via blocking the production of free radicals and scavenging the radicals with Ce3+/Ce4+ catalytic cycles, which provides a valuable insight into CeONPs as a therapeutic intervention in oxidative damage in Alzheimer's disease.

Graphical abstract: Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ1–42 with copper ions

Supplementary files

Article information

Article type
Communication
Submitted
19 sep 2015
Accepted
24 nov 2015
First published
25 nov 2015

Metallomics, 2016,8, 644-647

Author version available

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