Issue 4, 2015

Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies

Abstract

We report the synthesis of a novel, water-soluble aryl-extended calix[4]pyrrole receptor. The water-solubilising groups are placed at the lower rim of the receptor, leaving the binding pocket unperturbed and open for modification. Binding studies were performed with a series of pyridine N-oxides. These studies revealed the ability of the receptor to bind neutral and charged N-oxides in basified water with stability constants higher than 104 M−1.

Graphical abstract: Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies

Supplementary files

Article information

Article type
Paper
Submitted
03 okt 2014
Accepted
18 nov 2014
First published
18 nov 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 1022-1029

Author version available

Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies

D. Hernández-Alonso, S. Zankowski, L. Adriaenssens and P. Ballester, Org. Biomol. Chem., 2015, 13, 1022 DOI: 10.1039/C4OB02108H

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