Issue 41, 2015

Lipopeptides: from self-assembly to bioactivity

Abstract

This Feature Article discusses several classes of lipopeptide with important biomedical applications as antimicrobial and antifungal agents, in immune therapies and in personal care applications among others. Two main classes of lipopeptide are considered: (i) bacterially-expressed lipopeptides with a cyclic peptide headgroup and (ii) linear lipopeptides (with one or more lipid chains) based on bio-derived and bio-inspired amino acid sequences with current clinical applications. The applications are briefly summarized, and the biophysical characterization of the molecules is reviewed, with a particular focus on self-assembly. For several of these types of biomolecule, the formation of micelles above a critical micelle concentration has been observed while others form bilayer structures, depending on conditions of pH and temperature. As yet, there are few studies on the possible relationship between self-assembly into structures such as micelles and bioactivity of this class of molecule although this is likely to attract further attention.

Graphical abstract: Lipopeptides: from self-assembly to bioactivity

Article information

Article type
Feature Article
Submitted
19 feb 2015
Accepted
18 mrt 2015
First published
18 mrt 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 8574-8583

Lipopeptides: from self-assembly to bioactivity

I. W. Hamley, Chem. Commun., 2015, 51, 8574 DOI: 10.1039/C5CC01535A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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