Karunakaran A. Kalesh, James A. Clulow and Edward W. Tate
Chem. Commun., 2015,51, 5497-5500
DOI:
10.1039/C4CC09527H,
Communication
Zerumbone is a phytochemical with diverse biological activities ranging from anti-inflammatory to anti-cancer properties; however, to date the cellular targets of this important compound have remained elusive. Here we report the global protein target spectrum of zerumbone in living cancer cells using competitive activity-based protein profiling of a novel cell-permeable clickable probe, combined with quantitative mass spectrometry.
