Issue 12, 2015

Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

Abstract

Mutants of toluene o-xylene monooxygenase are demonstrated to oxidize ethylene to ethylene oxide in vivo at yields of >99%. The best mutant increases ethylene oxidation activity by >5500-fold relative to the native enzyme. This is the first report of a recombinant enzyme capable of carrying out this industrially significant chemical conversion.

Graphical abstract: Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

Supplementary files

Article information

Article type
Communication
Submitted
04 nov 2014
Accepted
12 dec 2014
First published
05 jan 2015

Chem. Commun., 2015,51, 2283-2285

Author version available

Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

D. A. Carlin, S. J. Bertolani and J. B. Siegel, Chem. Commun., 2015, 51, 2283 DOI: 10.1039/C4CC08802F

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