Issue 10, 2014

Brønsted acid-catalyzed synthesis of carbazoles from 2-substituted indoles

Abstract

A simple and efficient method for the synthesis of disubstituted carbazoles has been developed. In this approach, carbazoles are synthesized from o-haloanilines and terminal alkynes using a two-step strategy, namely, Sonogashira coupling and intramolecular cyclization to provide indoles, which are followed by a p-TSA·H2O-catalyzed carbazole formation.

Graphical abstract: Brønsted acid-catalyzed synthesis of carbazoles from 2-substituted indoles

Supplementary files

Article information

Article type
Research Article
Submitted
05 sep 2014
Accepted
03 okt 2014
First published
06 okt 2014

Org. Chem. Front., 2014,1, 1197-1200

Author version available

Brønsted acid-catalyzed synthesis of carbazoles from 2-substituted indoles

Q. Li, X. Peng and H. N. C. Wong, Org. Chem. Front., 2014, 1, 1197 DOI: 10.1039/C4QO00242C

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