Issue 4, 2013

Enzyme inhibition by metal complexes: concepts, strategies and applications

Abstract

Metal complexes are increasingly being used to inhibit enzymes. The reasons for this increased interest arise from the special features that metal complexes offer, e.g. the facile construction of 3D architectures that tightly fill enzyme active sites increasing selectivity and the possibility of facile coordination to protein residues that enhances enzyme inhibition. In this review we classify the main modes of enzyme inhibition by metal-based complexes and correlate the enzyme inhibition activity to macroscopic properties such as anticancer activity.

Graphical abstract: Enzyme inhibition by metal complexes: concepts, strategies and applications

Article information

Article type
Minireview
Submitted
31 dec 2012
Accepted
12 feb 2013
First published
18 feb 2013
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2013,4, 1410-1419

Enzyme inhibition by metal complexes: concepts, strategies and applications

K. J. Kilpin and P. J. Dyson, Chem. Sci., 2013, 4, 1410 DOI: 10.1039/C3SC22349C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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